Is folate absorption impaired by high dose methotrexate?
نویسندگان
چکیده
منابع مشابه
Methotrexate Associated Renal Impairment Is Related to Delayed Elimination of High-Dose Methotrexate
Although Methotrexate (MTX) is an effective drug for the treatment of acute lymphoblastic leukemia (ALL), the toxicity remains a significant problem. In this prospective study, fifty-four patients with ALL were enrolled. 3 g or 5 g MTX/m(2) was administered over 24 hours. Serum MTX concentrations were determined in 24, 48, and 96 hours after MTX infusion. Serum creatinine concentrations and cre...
متن کاملTreatment of acute lymphocytic leukemia by high-dose intravenous methotrexate.
A pharmacokinetic study of methotrexate levels in blood and cerebrospinal fluid was performed in 42 patients who received one or more courses of high-dose methotrexate at 500 mg/sq m infused i.v. over a 24-hr period. Methotrexate level in the lumbar cerebrospinal fluid reached 1.2 x 10(-7) M at 0.5 hr and remained constant at that level for the 1st 24 hr. Similar methotrexate levels were noted ...
متن کاملFolate absorption
Folic acid, or pteroylglutamic acid, is the parent substance of a large group of related compounds called 'folates'. All folate compounds have the same basic molecular structure consisting of three parts: pteridine, para-aminobenzoate (these two together forming a pteroyl group), and L-glutamic acid (Fig. 1). Pteroylglutamic acid itself is a stable, watersoluble compound with a molecular weight...
متن کاملHigh-dose methotrexate for intraocular lymphoma.
PURPOSE Intraocular lymphoma (IOL) frequently coexists with primary central nervous system lymphoma(PCNSL). We sought to determine the efficacy of high-dose methotrexate (MTX) alone in patients with IOL. We also sought to determine whether micromolar levels of MTX could be achieved in the aqueous and vitreous humor of the eye after i.v. administration of the drug. EXPERIMENTAL DESIGN Nine pat...
متن کاملHyper-CVAD and High-Dose Methotrexate/Cytarabine
Purpose: Diffuse and nodular forms of mantle-cell lymphoma (MCL) are consistently associated with poor prognosis. In an effort to improve the outcome, we adopted a treatment plan that consisted of four courses of fractionated cyclophosphamide (CY) 1,800 mg/m 2 administered with doxorubicin (DOX), vincristine (VCR), and dexamethasone (Hyper-CVAD) that alternated with high-dose methotrexate (MTX)...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1983
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1983.40